Dirk Schubert Lab of Cellular NeuroPhysiology
Schubert Neurolab @ Cognitive Neuroscience Department, Donders Institute for Brain Cognition & Behavior
Radboudumc Nijmegen, The Netherlands
© 2021 | Impressum: Dirk Schubert, CNS Dept radboudumc, Nijmegen, The Netherlands
@ RadboudUMC
@ Donders Inst. Radboud University
Peer-reviewed papers since 2017____________________________________
Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons. van Rhijn J-R, Shi Y, Bormann M, Mossink B, Frega M, Recaioglu H, Hakobjan M, Klein Gunnewiek T, Schoenmaker C, Palmer E, Faivre L, Kittel-Schneider S, Schubert D, Brunner H, Franke B, Nadif Kasri N. 2022. Neurobiol Dis 163:105587. doi:10.1016/J.NBD.2021.105587
SETD1A Mediated H3K4 Methylation and Its Role in Neurodevelopmental and Neuropsychiatric Disorders. Wang S, Bleeck A, Nadif Kasri
N, Kleefstra T, van Rhijn JR, Schubert D. 2021. . Front
Mol Neurosci 14. doi:10.3389/FNMOL.2021.772000
Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro. Mossink B, Verboven AHA, van Hugte EJH, Klein Gunnewiek TM, Parodi G, Linda K, Schoenmaker C, Kleefstra T, Kozicz T, van Bokhoven H, Schubert D, Nadif Kasri N, Frega M. (2021) Stem Cell Reports. 2021 Jul 13:S2213-6711(21)00326-X. doi: 10.1016/j.stemcr.2021.07.001. PMID: 34329594.
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, van Bokhoven H, Schubert D, Testa G, Koolen DA, de Vries BBA, Nadif Kasri N. (2021) Autophagy. 2021 Jul 21:1-20. doi: 10.1080/15548627.2021.1936777. PMID: 34286667.
Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks. Mossink B, van Rhijn J-R, Shan Wang S, Linda K, Vitale MR3,4, Zöller JEM, van Hugte EJH, Bak J, Verboven AHA, Selten M, Negwer M, Latour BL, van der Werf I, Keller JM, Klein Gunnewiek T, Schoenmaker C, Oudakker A, Anania A, Jansen S, Lesch K-P, Frega M, van Bokhoven H, Schubert D†, Nadif Kasri†. (Mol Psychiatry (2021). https://doi.org/10.1038/s41380-021-01117-x. †Authors contributed equally to this work
Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats. Van der Knaap N, Wiedermann D, Schubert D*, Hoehn M*, Homberg JR* (2021) Sci Rep 11:1680. *Authors contributed equally to this work
The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective. Mossink B, Negwer M, Schubert D, Nadif Kasri N. Cell Mol Life Sci. (2020) doi:10.1007/s00018-020-03714-5
EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas. Negwer M, Piera K, Hesen R, Lütje L, Aarts L, Schubert D, Nadif Kasri N. Brain Struct Funct 1:3. (2020) doi:10.1007/s00429-020-02149-9
Kummeling, J., Stremmelaar, D.E., Raun, N. et al. Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome. Mol Psychiatry (2020). https://doi.org/10.1038/s41380-020-0725-5
Klein
Gunnewiek TM, Van Hugte EJH, Frega M, Guardia GS, Foreman K, Panneman D,
Mossink B, Linda K, Keller JM, Schubert D, Cassiman D, Rodenburg R, Vidal Folch
N, Oglesbee D, Perales-Clemente E, Nelson TJ, Morava E, Nadif Kasri N, Kozicz
T. 2020 m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity Cell Rep. (2020) 31(3) 107538, DOI: 10.1016
Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, van Bokhoven H, Zhou H, Schubert D*, Nadif Kasri N*. Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. Cell Rep. (2020) 30(1):173-186.e6. doi: 10.1016
Gritsenko PG, Atlasy N, Dieteren CEJ, Navis AC, Venhuizen JH, Veelken C, Schubert D, Acker-Palmer A, Westerman BA, Wurdinger T, Leenders W, Wesseling P, Stunnenberg HG, Friedl P p120-catenin-dependent collective brain infiltration by glioma cell networks. Nat Cell Biol 22, 97–107 (2020) doi:10.1038/s41556-019-0443-x
Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van
Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, van
den Akker W, van der Werf I, Oudakker A, Zhou H, Kleefstra T, Schubert D, van
Bokhoven H, Nadif Kasri N. Neuronal network dysfunction in a model for
Kleefstra syndrome mediated by enhanced NMDAR signaling. Nat Commun (2019). 10.
doi:10.1038/s41467-019-12947-3
Mäki-Marttunen T, Kaufmann T, Elvsåshagen T,
Devor A, Djurovic S, Westlye LT, Linne M-L, Rietschel M, Schubert D, Borgwardt
S, Efrim-Budisteanu M, Bettella F, Halnes G, Hagen E, Næss S, Ness T V.,
Moberget T, Metzner C, Edwards AG, Fyhn M, Dale AM, Einevoll GT, Andreassen OA.
Biophysical Psychiatry How Computational Neuroscience Can Help to Understand
the Complex Mechanisms of Mental Disorders. Front Psychiatry 2019. 10.
doi:10.3389/fpsyt.2019.00534
Barsegyan
A, Mirone
G, Ronzoni
G, Guo
C, Song
Q, van Kuppeveld
D, Schut
EHS, Atsak
P, Teurlings
S, McGaugh
JL, Schubert
D, Roozendaal
D.
Glucocorticoid enhancement of recognition memory via basolateral
amygdala-driven facilitation of prelimbic cortex interactions. PNAS 2019 Apr, 116 (14) 7077-7082
Azarfar A, Zhang Y,
Alishbayli A, Miceli S, Kepser L, van der Wielen D, van de Moosdijk M, Homberg
J, Schubert D, Proville R, Celikel T. An open-source high-speed infrared videography database to study the
principles of active sensing in freely navigating rodents. Gigascience. 2018 Dec 1;7(12).
van der Knaap NJF, Klumpers F, El Marroun H, Mous S, Schubert D,
Jaddoe V, Hofman A, Homberg JR, Tiemeier H, White T, Fernández G. Maternal
depressive symptoms during pregnancy are associated with amygdala
hyperresponsivity in children. Eur Child Adolesc Psychiatry. 2018
Jan;27(1):57-64.
Negwer M, Liu YJ,
Schubert D, Lyon DC. V1 connections
reveal a series of elongated higher visual areas in the California ground
squirrel, Otospermophilus beecheyi. J Comp Neurol. 2017 Jun 1;525(8):1909-1921.
Miceli S, Nadif Kasri N, Joosten J, Huang C, Kepser L, Proville R,
Selten MM, van Eijs F, Azarfar A, Homberg JR, Celikel T, Schubert D.
Reduced Inhibition within Layer IV of Sert Knockout Rat Barrel Cortex is
Associated with Faster Sensory Integration. Cereb Cortex. 2017 Feb
1;27(2):933-949.
Miceli S, Ness TV, Einevoll GT, Schubert D. Impedance Spectrum
in Cortical Tissue: Implications for Propagation of LFP Signals on the
Microscopic Level. eNeuro. 2017 Jan 31;4(1).
Negwer M, Schubert D. Talking Convergence: Growing Evidence Links FOXP2 and Retinoic Acid in Shaping Speech-Related Motor Circuitry. Front Neurosci. 2017 Jan 25;11:19.
Frega M, van Gestel SH, Linda K, van der Raadt J, Keller J, Van Rhijn JR, Schubert D, Albers CA, Nadif Kasri N. Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays. J Vis Exp. 2017 Jan 8;(119).
Homberg JR, Schubert D, Asan E, Aron EN. Sensory processing sensitivity and serotonin gene variance: Insights into mechanisms shaping environmental sensitivity. Neurosci Biobehav Rev. 2016 Dec;71:472-483.
Walker F, Möck M, Feyerabend M, Guy J, Wagener RJ, Schubert D, Staiger JF, Witte M. Parvalbumin- and vasoactive intestinal polypeptide-expressing neocortical interneurons impose differential inhibition on Martinotti cells. Nat Commun. 2016 Nov 29;7:13664.
Martens MB, Frega M, Classen J, Epping L, Bijvank E, Benevento M, van Bokhoven, H, Tiesinga P†, Schubert D†, Nadif Kasri N†. Euchromatin histone methyltransferase 1 regulates cortical neuronal network development. Sci Rep. 2016 Oct 21† authors contributed equally to this work
Staiger JF, Loucif AJ, Schubert D, Möck M. Morphological Characteristics of Electrophysiologically Characterized Layer Vb Pyramidal Cells in Rat Barrel Cortex. PLoS One. 2016 Oct 5;11(10):e0164004.
Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt, RW, van Hulten JA, van Bakel NH, Roosen J, van der Linden RJ, Schubert D, Verheij MM, Kasri NN, Martens GJ. Increased GABA(B) receptor signaling in a rat model for schizophrenia. Sci Rep. 2016 Sep 30;6:34240.
Book chapters_____________________________________________
SENSORIMOTOR INTEGRATION IN THE WHISKER SYSTEM
(Krieger and Groh, eds) chapter “Impact of Neuromodulators on the Development
of Sensorimotor Circuits”; D. Schubert, J. Homberg, N. Nadif Kasri, T. Celikel;
Springer, 2015 ISBN 9781493929740
