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Dirk Schubert Lab of Cellular NeuroPhysiology
Schubert Neurolab @ Cognitive Neuroscience Department, Donders Institute for Brain Cognition & Behavior
Radboudumc Nijmegen, The Netherlands
© 2021  | Impressum: Dirk Schubert, CNS Dept Radboudumc, Nijmegen, The Netherlands
@ RadboudUMC
@ Donders Inst. Radboud University
Peer-reviewed papers since 2020____________________________________
                    
                    Repeated testing modulates chronic unpredictable mild stress effects in male rats. Bosch K, Sbrini G, Burattini I, Nieuwenhuis D, Calabrese F, Schubert D, Henckens MJAG, Homberg JR. Behav Brain Res. 2022 Aug 26;432:113960. doi: 10.1016/j.bbr.2022.113960. Epub 2022 Jun 10. PMID: 35697177.

                    Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway. Wang S, Rhijn JV, Akkouh I, Kogo N, Maas N, Bleeck A, Ortiz IS, Lewerissa E, Wu KM, Schoenmaker C, Djurovic S, van Bokhoven H, Kleefstra T, Nadif Kasri N, Schubert D. Cell Rep. 2022 May 3;39(5):110790. doi: 10.1016/j.celrep.2022.110790. PMID: 35508131.

             Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons. van Rhijn J-R, Shi Y, Bormann M, Mossink B, Frega M, Recaioglu H, Hakobjan M, Klein Gunnewiek T, Schoenmaker C, Palmer E, Faivre L, Kittel-Schneider S, Schubert D, Brunner H, Franke B, Nadif Kasri N. 2022. Neurobiol Dis 163:105587. doi:10.1016/J.NBD.2021.105587                  

                 SETD1A Mediated H3K4 Methylation and Its Role in Neurodevelopmental and Neuropsychiatric Disorders. Wang S, Bleeck A, Nadif Kasri N, Kleefstra T, van Rhijn JR, Schubert D. 2021. . Front Mol Neurosci 14. doi:10.3389/FNMOL.2021.772000
 
                  Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro. Mossink B, Verboven AHA, van Hugte EJH, Klein Gunnewiek TM, Parodi G, Linda K, Schoenmaker C, Kleefstra T, Kozicz T, van Bokhoven H, Schubert D, Nadif Kasri N, Frega M. (2021) Stem Cell Reports. 2021 Jul 13:S2213-6711(21)00326-X. doi: 10.1016/j.stemcr.2021.07.001. PMID: 34329594.

                 Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, van Bokhoven H, Schubert D, Testa G, Koolen DA, de Vries BBA, Nadif Kasri N. (2021) Autophagy. 2021 Jul 21:1-20. doi: 10.1080/15548627.2021.1936777. PMID: 34286667.

                   Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks. Mossink B, van Rhijn J-R, Shan Wang S, Linda K, Vitale MR3,4, Zöller JEM, van Hugte EJH, Bak J, Verboven AHA, Selten M, Negwer M, Latour BL, van der Werf I, Keller JM, Klein Gunnewiek T, Schoenmaker C, Oudakker A, Anania A, Jansen S, Lesch K-P, Frega M, van Bokhoven H, Schubert D†, Nadif Kasri†. (Mol Psychiatry (2021). https://doi.org/10.1038/s41380-021-01117-x. †Authors contributed equally to this work

                    Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats. Van der Knaap N, Wiedermann D, Schubert D*, Hoehn M*, Homberg JR* (2021) Sci Rep 11:1680. *Authors contributed equally to this work

                    The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective. Mossink B, Negwer M, Schubert D, Nadif Kasri N. Cell Mol Life Sci. (2020) doi:10.1007/s00018-020-03714-5

                 EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas. Negwer M, Piera K, Hesen R, Lütje L, Aarts L, Schubert D, Nadif Kasri N. Brain Struct Funct 1:3. (2020) doi:10.1007/s00429-020-02149-9

                  Kummeling, J., Stremmelaar, D.E., Raun, N. et al. Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome. Mol Psychiatry (2020). https://doi.org/10.1038/s41380-020-0725-5

                   Klein Gunnewiek TM, Van Hugte EJH, Frega M, Guardia GS, Foreman K, Panneman D, Mossink B, Linda K, Keller JM, Schubert D, Cassiman D, Rodenburg R, Vidal Folch N, Oglesbee D, Perales-Clemente E, Nelson TJ, Morava E, Nadif Kasri N, Kozicz T. 2020 m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity Cell Rep. (2020) 31(3) 107538, DOI: 10.1016

                  Frega M, Selten M, Mossink B, Keller JM, Linda K, Moerschen R, Qu J, Koerner P, Jansen S, Oudakker A, Kleefstra T, van Bokhoven H, Zhou H, Schubert D*, Nadif Kasri N*. Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. Cell Rep. (2020) 30(1):173-186.e6. doi: 10.1016

                 Gritsenko PG, Atlasy N, Dieteren CEJ, Navis AC, Venhuizen JH, Veelken C, Schubert D, Acker-Palmer A, Westerman BA, Wurdinger T, Leenders W, Wesseling P, Stunnenberg HG, Friedl P p120-catenin-dependent collective brain infiltration by glioma cell networks. Nat Cell Biol 22, 97–107 (2020) doi:10.1038/s41556-019-0443-x

                  Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, van den Akker W, van der Werf I, Oudakker A, Zhou H, Kleefstra T, Schubert D, van Bokhoven H, Nadif Kasri N. Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling. Nat Commun (2019). 10. doi:10.1038/s41467-019-12947-3

             Mäki-Marttunen T, Kaufmann T, Elvsåshagen T, Devor A, Djurovic S, Westlye LT, Linne M-L, Rietschel M, Schubert D, Borgwardt S, Efrim-Budisteanu M, Bettella F, Halnes G, Hagen E, Næss S, Ness T V., Moberget T, Metzner C, Edwards AG, Fyhn M, Dale AM, Einevoll GT, Andreassen OA. Biophysical Psychiatry How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders. Front Psychiatry 2019. 10. doi:10.3389/fpsyt.2019.00534

Book chapters_____________________________________________
SENSORIMOTOR INTEGRATION IN THE WHISKER SYSTEM (Krieger and Groh, eds) chapter “Impact of Neuromodulators on the Development of Sensorimotor Circuits”; D. Schubert, J. Homberg, N. Nadif Kasri, T. Celikel; Springer, 2015 ISBN 9781493929740
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Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway.
cell press logo images Elsevier